Specific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay

Author:

Ali Firoj1234,A. Anila H.1234,Taye Nandaraj5674,Mogare Devraj G.5674,Chattopadhyay Samit5674,Das Amitava1234

Affiliation:

1. Organic Chemistry Division

2. CSIR-National Chemical Laboratory

3. Pune-411008

4. India

5. Chromatin and Disease Biology Lab

6. National Centre for Cell Science

7. Pune 411007

Abstract

New chemodosimetric reagent for the specific detection of hydrazine in physiological conditions as well as for the mapping of its in situ generation in live Hct116 and HepG2 cells by enzymatic transformations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference30 articles.

1. International Agency for Research on Cancer , Re-evaluation of some organic chemicals, hydrazine, and hydrogen peroxide, IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, IARC, Lyon, 1999, vol. 71, p. 991

2. Studies on hydrazine hepatotoxicity. 1. Pathological findings

3. Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats

4. S. J. Moloney and R. A.Prough, in Biochemical Toxicology of Hydrazine, ed. E. Hodgson and R. M. Philpot, Elsevier Science, New York, 1983, p. 313

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