Mol-Zero-GAN: zero-shot adaptation of molecular generative adversarial network for specific protein targets-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Mol-Zero-GAN: zero-shot adaptation of molecular generative adversarial network for specific protein targets

Published:2023 Issue:51 Volume:13 Page:36048-36059
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Aphikulvanich Ravipas¹^ORCID,Pornputtapong Natapol²,Wichadakul Duangdao¹³^ORCID

Affiliation:

1. Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand

2. Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand

3. Center of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand

Abstract

A framework that optimizes the drug generative adversarial network (GAN) to produce drugs targeting specific proteins, while preserving drug-likeness using Bayesian optimization and singular value decomposition (SVD).

Funder

Office of National Higher Education Science Research and Innovation Policy Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA03954D

Reference44 articles.

1. Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks

2. GEN: highly efficient SMILES explorer using autodidactic generative examination networks

3. From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design

4. Molecular generative model based on conditional variational autoencoder for de novo molecular design

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP