Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism
Author:
Affiliation:
1. Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education
2. Institute of Biotechnology
3. Shanxi University
4. Taiyuan
5. China
6. School of Life Science
Abstract
The study implies that bound polyphenol from millet bran dramatically prevents ganglioside GM3 catabolism followed by the suppression of P-gp, which eventually reverse drug-resistance in colorectal cancer cells to oxaliplatin.
Funder
National Natural Science Foundation of China
Fund for Shanxi Key Subjects Construction
Publisher
Royal Society of Chemistry (RSC)
Subject
General Medicine,Food Science
Link
http://pubs.rsc.org/en/content/articlepdf/2021/FO/D0FO02232B
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