Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl–prolyl isomerase Pin1
Author:
Affiliation:
1. Department of Chemistry and Biochemistry
2. The Ohio State University
3. Columbus
4. USA
5. Department of Pharmaceutical Chemistry
6. Faculty of Pharmacy
7. Helwan University
8. Egypt
Abstract
Integration of Pin1-binding and cell-penetrating sequences results in a cell-permeable, biologically active cycloheptapeptide inhibitor against Pin1.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00430C
Reference27 articles.
1. The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members
2. Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases
3. The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target
4. Pin1 inhibitors: Pitfalls, progress and cellular pharmacology
5. Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions
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