Bis((1,4-dimethyl-9H-carbazol-3-yl)methyl)amine-mediated anticancer effect triggered by sequence-specific cleavage of DNA leading to programmed cell death in the human U87 cell line-Reference-Cited by-同舟云学术

Bis((1,4-dimethyl-9H-carbazol-3-yl)methyl)amine-mediated anticancer effect triggered by sequence-specific cleavage of DNA leading to programmed cell death in the human U87 cell line

Published:2016 Issue:72 Volume:6 Page:67925-67940
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kumar Nitin¹²³⁴⁵,Kumar Rakesh¹²³⁴⁵,Nemaysh Vishal¹²³⁴⁵,Lal Neetika¹²³⁴⁵,Luthra Pratibha Mehta¹²³⁴⁵

Affiliation:

1. Neuropharmaceutical Chemistry Laboratory

2. Dr B.R. Ambedkar Centre for Biomedical Research

3. University of Delhi

4. Delhi – 110007

5. India

Abstract

Bis((1,4-dimethyl-9H-carbazol-3-yl)methyl)amine (DMCM) has been designed as a novel anti-cancer agent which is believed to have a sequence-specific groove binding interaction with DNA, leading to anticancer effects.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA12999D

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