Affiliation:
1. School of Medical and Allied Sciences (SMAS), K.R. Mangalam University, Sohna road, Gurugram, Haryana, India
2. Sanskar College of Pharmacy and Research (SCPR), NH-24, Ahead Masuri Canal, Ghaziabad 201302, India
Abstract
Abstract:
Alzheimer’s is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on a combination
of two or more bioactive pharmacophores into a single molecule and this phenomenon has received a
great attention in the new era of modern drug discovery and emerging as a choice to treat this complex
Alzheimer’s disease (AD). In last fifteen years, many research groups designed, and synthesized new
carbazole integrated molecules linked with other bioactive pharmacophores like thiazoles, carvedilol, α-
naphthylaminopropan-2-ol, tacrine, ferulic acid, piperazine, coumarin, chalcones, stilbene, benzyl piperidine,
adamantane, quinoline, phthalocyanines, α-amino phosphonate, thiosemicarbazones, hydrazones,
etc. derivatives using MTDLs approach to confront AD. The present review entails the scientific data on
carbazole hybrids as potential Anti-Alzheimer activities from 2007 to 2021 that have shown potential
anti-Alzheimer activities through multiple target pathways thereby promising hope for new drug development
to confront AD.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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