Coumarin-acetohydrazide derivatives as novel antiproliferative agents <i>via</i> VEGFR-2/AKT axis inhibition and apoptosis triggering-Reference-Cited by-同舟云学术

Coumarin-acetohydrazide derivatives as novel antiproliferative agents via VEGFR-2/AKT axis inhibition and apoptosis triggering

Published:2022 Issue:36 Volume:46 Page:17394-17409
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Abdel Ghany Lina M. A.¹,El-Dydamony Nehad M.¹,Helwa Amira A.²^ORCID,Abdelraouf Sahar M.³,Abdelnaby Rana M.⁴^ORCID

Affiliation:

1. Pharmaceutical Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt

2. Pharmaceutical Organic Chemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Egypt

3. Biochemistry Department, Faculty of pharmacy, Misr International University, Cairo, Egypt

4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt

Abstract

The VEGFR-2/AKT pathway is a crucial axis in tumor survival where it is highly dysregulated in many cancer types.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ02436E

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1. Targeting Cell Survival Proteins for Cancer Cell Death