Didanosine-loaded poly(epsilon-caprolactone) microparticles by a coaxial electrohydrodynamic atomization (CEHDA) technique

Author:

Seremeta Katia P.12345,Höcht Christian62345,Taira Carlos74562,Cortez Tornello Pablo R.74589,Abraham Gustavo A.74589,Sosnik Alejandro1011121314

Affiliation:

1. Department of Pharmaceutical Technology

2. Faculty of Pharmacy and Biochemistry

3. University of Buenos Aires

4. Buenos Aires

5. Argentina

6. Department of Pharmacology

7. National Science Research Council (CONICET)

8. Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA, Universidad Nacional de Mar del Plata-CONICET)

9. Mar del Plata

10. Group of Pharmaceutical Nanomaterials Science

11. Department of Materials Science and Engineering

12. Technion-Israel Institute of Technology

13. Haifa

14. Israel

Abstract

EHDA technology was used to encapsulate the water-soluble antiretroviral ddI within PCL particles and stabilize it in the gastric medium where it undergoes fast degradation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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