Affiliation:
1. Instituto de Agrobiotecnología del Litoral CONICET – Universidad Nacional del Litoral Santa Fe Argentina
2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Instituto de Investigaciones Biológicas – Universidad Nacional de Mar del Plata Buenos Aires Argentina
3. Instituto de Investigaciones en Ciencia y Tecnología de Materiales (UNMdP – CONICET) Buenos Aires Argentina
Abstract
AbstractPolyhydroxyalkanoates (PHAs) are biopolymers accumulated by a diversity of bacterial strains as carbon and energy reserve when grown under unbalanced nutritional conditions. Among the wide spectrum of applications for these biopolymers, the generation of nano and microparticles has drawn huge attention. PHA nanoparticles showed a high surface‐to‐volume ratio that makes them interesting for pharmaceutical uses. Bacteria from the Halomonas genus became interesting tools for biopolymer production in the last years, due to its metabolic plasticity that allows them to grow in a wide spectrum of compounds and salt concentrations. Halomonas titanicae KHS3 was previously isolated based on their ability to grow using aromatic hydrocarbons as the sole carbon source. In this work, the novelty lies in the evaluation of PHA accumulation by H. titanicae KHS3. Accumulation was successfully observed and thoroughly characterized on various carbon sources. Irrespective of the carbon source employed for growth, our experimental conditions consistently yielded PHB as the sole material identified. The truly intriguing aspect of this study is that PHB solutions in glacial acetic acid demonstrated exceptional suitability for electrospraying processing. This groundbreaking development led to the creation of nanoparticles with unique characteristics that hold immense promise for a wide range of applications.
Funder
Agencia Santafesina de Ciencia, Tecnología e Innovación
Consejo Nacional de Investigaciones Científicas y Técnicas
Universidad Nacional de Mar del Plata
Universidad Nacional del Litoral
Subject
Materials Chemistry,Polymers and Plastics,Surfaces, Coatings and Films,General Chemistry