Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines-Reference-Cited by-同舟云学术

Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines

Published:2015 Issue:46 Volume:13 Page:11351-11361
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhao Bo-Liang¹²³⁴,Lin Ye¹²³⁴,Yan Hao-Hao¹²³⁴,Du Da-Ming¹²³⁴⁵

Affiliation:

1. School of Chemical Engineering and Environment

2. Beijing Institute of Technology

3. Beijing 100081

4. People's Republic of China

5. State Key Laboratory of Elemento-Organic Chemistry

Abstract

A squaramide catalysed aza-Michael/Michael cascade reaction between nitroalkenes and tosylaminomethyl enones or enoates afforded highly functionalized chiral pyrrolidines in good yields (up to 99%) with good diastereoselectivities (up to 91 : 9 dr) and excellent enantioselectivities (up to >99% ee) under mild conditions.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01749A

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