Author:
Lira-Navarrete Erandi,Hurtado-Guerrero Ramon
Abstract
Protein O-fucosylation is an important post-translational modification (PTM) found in cysteine-rich repeats in proteins. Protein O-fucosyltransferases 1 and 2 (PoFUT1 and PoFUT2) are the enzymes responsible for this PTM and selectively glycosylate specific residues in epidermal growth factor-like (EGF) repeats and thrombospondin type I repeats (TSRs), respectively. Within the past six years, crystal structures of both enzymes have been reported, revealing important information on how they recognize protein substrates and achieve catalysis. Here, the structural information available today is summarized and how PoFUT1 and PoFUT2 employ different catalytic mechanisms is discussed.
Funder
European Molecular Biology Organization
European Commission, FP7 People: Marie-Curie Actions
Fundación Agencia Aragonesa para la Investigación y el Desarrollo
Ministerio de Ciencia e Innovación
Diputación General de Aragón
Publisher
International Union of Crystallography (IUCr)
Subject
Condensed Matter Physics,Genetics,Biochemistry,Structural Biology,Biophysics
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