Darifenacin hydrobromide

Abstract

In the title compound {systematic name: (S)-3-[(aminocarbonyl)diphenylmethyl]-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidinium bromide}, C28H31N2O2+·Br−, the pyrrolidine rings adopts an envelope conformation. The two phenyl rings make a dihedral angle of 72.5 (1)°. The four coplanar atoms of the pyrrolidine ring makes dihedral angles of 33.1 (2) and 82.8 (2)° with the two phenyl rings. The molecular conformation is influenced by a C—H...O interaction. In the crystal packing, there are two N—H...Br hydrogen bonds running in opposite directions. They appear to formC(10) andC(9) chain motifs in the unit cell. In addition, the molecular packing is further stabilized by C—H...Br and C—H...O hydrogen bonds. The C atom bonded to the benzofuran ring system is disordered in a 0.66:0.34 ratio.