Affiliation:
1. V. N. Karazin Kharkiv National University
2. Instituto de Quнmica
3. Universidade Estadual de Campinas
Abstract
In the present study, an electrochemical sensor based on the electrode (SiMImCl/C) consisting of graphite and silica, grafted with 1-n-propyl-3-methylimidazolium chloride was used for ascorbic acid (AA) quantification in pharmaceuticals and food formulations. Cyclic voltammetry and electrochemical impedance spectroscopy were applied for electrochemical characterization of the SiMImCl/C electrode. The cyclic voltammetry study revealed that the oxidation of AA on this electrode is an irreversible process, realized by adsorption and diffusion limited step. The differential pulse voltammetry was applied to develop a procedure for the AA determination. The linear range was found to be 0.3–170 μmol L-1 and the limit of detection – 0.1 μmol L-1. The proposed SiMImCl/C electrode has long term stability and does not show electrochemical activity towards the analytes, which commonly coexist with AA. The sensor was successfully used for quantification of AA in food and pharmaceutical formulations.
Publisher
Taras Shevchenko National University of Kyiv
Reference42 articles.
1. Pappenberger, G.; Hohmann, H. P. Industrial Production of l-Ascorbic Acid (Vitamin C) and d-Isoascorbic Acid. In: H. Zorn, P. Czermak (Eds.). Biotechnology of Food and Feed Additives. Advances in Biochemical Engineering/Biotechnology. 2013, 143, 143–188.
2. Ohno, S.; Ohno, Y.; Suzuki, N.; et al. High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. Anticancer Res. 2009, 29, 809–15.
3. Chen, G. C.; Lu, D. B.; Pang, Z. et al. Vitamin C Intake, Circulating Vitamin C and Risk of Stroke: A Meta-Analysis of Prospective Studies. J. Am. Heart Assoc. 2013, 2, e000329.
4. Chen, F.; Li, Q.; Yu, Y.; et al. Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis. Sci. Rep. 2015, 5, 9599.
5. He, D.; Li, S.; Zhang, P.; et al. CVD graphene incorporating polymerized l-cysteine as an electrochemical sensing platform for simultaneous determination of dopamine and ascorbic acid. Anal. Meth. 2017, 9, 6689–6697.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献