Reaction of 1-aminoisoindole with methyl 4-chloro-3-oxobutanoate-Reference-Cited by-同舟云学术

Reaction of 1-aminoisoindole with methyl 4-chloro-3-oxobutanoate

Published:2018 Issue:2 Volume:6 Page:32-37
ISSN:2312-3222
Container-title:French-Ukrainian Journal of Chemistry
language:
Short-container-title:Fr. Ukr. J. Chem.

Author:

Kysil Andrii¹,Biitseva Angelina¹,Yegorova Tetyana¹,Levkov Igor¹,Voitenko Zoia¹

Affiliation:

1. Taras Shevchenko National University of Kyiv

Abstract

Condensation of bifunctional 1-aminoisoindole with bis-electrophilic methyl 4-chloro-3-oxobutanoate undergoes regioselectively to afford 2-(chloromethyl)-2-hydroxy-2,6-dihydropyrimido[2,1-a]isoindol-4(3H)-one. The structure of the reaction product was unambiguously established by HMQC and HMBC heteronuclear correlations. The functionalization of the synthesized compound by reactions with a series of aliphatic amines was carried out.

Publisher

Taras Shevchenko National University of Kyiv

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