Atopaxar and its effects on markers of platelet activation and inflammation: results from the LANCELOT CAD program

Author:

O’Donoghue Michelle L.,Bhatt Deepak L.,Flather Marcus D.,Goto Shinya,Angiolillo Dominick J.,Goodman Shaun G.,Zeymer Uwe,Aylward Philip E.,Montalescot Gilles,Ziecina Rafal,Kobayashi Hiroyuki,Ren Fang,Wiviott Stephen D.

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,Hematology

Reference12 articles.

1. Angiolillo DJ, Capodanno D, Goto S (2010) Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J 31(1):17–28. doi: 10.1093/eurheartj/ehp504

2. O’Donoghue ML, Bhatt DL, Wiviott SD, Goodman SG, Fitzgerald DJ, Angiolillo DJ, Goto S, Montalescot G, Zeymer U, Aylward PE, Guetta V, Dudek D, Ziecina R, Contant CF, Flather MD (2011) Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial. Circulation 123(17):1843–1853. doi: 10.1161/CIRCULATIONAHA.110.000786

3. Wiviott SD, Flather MD, O’Donoghue ML, Goto S, Fitzgerald DJ, Cura F, Aylward P, Guetta V, Dudek D, Contant CF, Angiolillo DJ, Bhatt DL (2011) Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of thrombin-coronary artery disease trial. Circulation 123(17):1854–1863. doi: 10.1161/CIRCULATIONAHA.110.001404

4. Serebruany VL, Kogushi M, Dastros-Pitei D, Flather M, Bhatt DL (2009) The in vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb Haemost 102(1):111–119. doi: 10.1160/TH08-12-0805

5. Goto S, Ogawa H, Takeuchi M, Flather MD, Bhatt DL (2010) Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease. Eur Heart J 31(21):2601–2613. doi: 10.1093/eurheartj/ehq320

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