The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children-Reference-Cited by-同舟云学术

The efficacy of activated zinc pyrithione in the treatment of IgE-independent atopic dermatitis in children

Published:2022-03-12 Issue:3 Volume: Page:88-94
ISSN:2658-5790
Container-title:Meditsinskiy sovet = Medical Council
language:
Short-container-title:Medicinskij sovet

Author:

Zhukova O. V.¹^ORCID,Kasikhina E. I.¹^ORCID,Ostretsova M. N.²^ORCID,Tereshchenko G. P.¹^ORCID,Nemer A. M.²^ORCID

Affiliation:

1. Peoples’ Friendship University of Russia; Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

2. Peoples’ Friendship University of Russia

Abstract

Introduction. Colonization of the skin with S. aureus and S. epidermidis in children with atopic dermatitis leads to the initiation of inflammation and worsening of the disease. The control of overcolonization with S. aureus is an important issue in pediatric dermatological practice. At the same time, to achieve a controlled level of colonization, it is preferable to prescribe non-steroidal external agents. Activated zinc pyrithione has a wide range of complementary pharmacodynamic effects, including anti-inflammatory, pro-apoptogenic, antimicrobial, and antifungal. The article presents the results of the use of zinc pyrithione in mild IgE-independent atopic dermatitis in children. The results of the main clinical studies confirming the effect of zinc pyrithione on the microbiome in AD and the severity of the disease were analyzed.Aim. To evaluate the therapeutic and microbiological efficacy of activated zinc pyrithione as monotherapy in patients with IgEindependent atopic dermatitis.Materials and methods. 30 patients aged 2 to 8 years with mild atopic dermatitis in the acute stage were divided into 2 groups. Group 1 received activated zinc pyrithione, group 2 received a combined topical steroid.Results. Both groups showed a significant reduction in S. aureus skin colonization. In both groups, in comparison with the initial state, a significant decrease in the severity of clinical manifestations of AD was obtained. The therapeutic efficacy of zinc pyrithione was 93.3%, clinical remission was observed in 73.3% of cases.Conclusion. The totality of currently available data on the clinical efficacy and safety of activated zinc pyrithione allows us to recommend it as one of the effective agents for external therapy of mild IgE-independent atopic dermatitis. The use of activated zinc pyrithione showed a rapid, pronounced positive result of treatment, a decrease in the risk of secondary infection in observed children with IgE-independent atopic dermatitis.

Publisher

Remedium, Ltd.

Subject

General Medicine

Reference47 articles.

1. Murashkin N.N., Epishev R.V., Fedorov D.V., Materikin A.I., Ambarchyan E.T., Opryatin L.A. et al. Sensitive Skin Syndrome in Children with Atopic Dermatitis: Pathogenesis and Management Features. Current Pediatrics. 2019;18(4):285–293. (In Russ.) https://doi.org/10.15690/vsp.v18i4.2046.

2. Kay J., Gawkrodger D.J., Mortimer M.J., Jaron A.G. The prevalence of childhood atopic eczema in a general population. J Am Acad Dermatol. 1994;30(1):35–39. https://doi.org/10.1016/s0190-9622(94)70004-4.

3. Aw M., Penn J., Gauvreau G.M., Lima H., Sehmi R. Atopic March: Collegium Internationale Allergologicum Update 2020. Int Arch Allergy Immunol. 2020;181(1):1–10. https://doi.org/10.1159/000502958.

4. Ahn K., Kim B.E., Kim J., Leung D.Y. Recent advances in atopic dermatitis. Curr Opin Immunol. 2020;66:14–21. https://doi.org/10.1016/j.coi.2020.02.007.

5. Di Agosta E., Salvati L., Corazza M., Baiardini I., Ambrogio F., Angileri L. et al. Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder. Clin Mol Allergy. 2021;19(1):26. https://doi.org/10.1186/s12948-021-00165-6.