Author:
Di Agosta Ester,Salvati Lorenzo,Corazza Monica,Baiardini Ilaria,Ambrogio Francesca,Angileri Luisa,Antonelli Elettra,Belluzzo Federica,Bonamonte Domenico,Bonzano Laura,Brancaccio Raffaele,Custurone Paolo,De Marco Aurora,Detoraki Aikaterini,Di Guida Adriana,Di Leo Elisabetta,Fantò Marta,Fassio Filippo,Ferrucci Silvia Mariel,Foti Caterina,Gallo Rosella,Gatta Alessia,Guarneri Fabrizio,Guidolin Lucia,Hansel Katharina,Lamacchia Donatella,Lombardo Carla,Minciullo Paola Lucia,Napolitano Maddalena,Pannofino Alessandro,Paravisi Andrea,Parente Roberta,Passante Maria,Patruno Cataldo,Peroni Diego,Quecchia Cristina,Schettini Natale,Spadaro Giuseppe,Stingeni Luca,Tarrini Daniele,Tramontana Marta,Nettis Eustachio,Rossi Oliviero
Abstract
AbstractAllergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often overlooked. Considering the increasing prevalence of atopic dermatitis, allergic contact dermatitis, hereditary angioedema, cutaneous mastocytosis, and urticaria, it is essential to determine the effects of allergic and immunologic skin diseases on QoL. A joint meeting (GET TOGETHER 2021) of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) aimed to summarize the features of the main QoL tools used in these diseases and to describe the extent of QoL impairment as well as the impact of treatments on QoL, particularly biologic therapies. The assessment of QoL in patients with allergic and immunologic skin diseases relies on generic, organ-specific and disease-specific questionnaires. While generic and organ-specific questionnaires allow comparison between different diseases, disease-specific questionnaires are designed and validated for specific cohorts: the QoL Index for Atopic Dermatitis (QoLIAD) and the Childhood Atopic Dermatitis Impact Scale (CADIS) in atopic dermatitis, the ACD-11 in allergic contact dermatitis, the Angioedema QoL Questionnaire (AE-QoL) and the Hereditary Angioedema QoL questionnaire (HAE-QoL) in hereditary angioedema, the Mastocytosis QoL Questionnaires (MCQoL e MQLQ) in cutaneous mastocytosis, and the Chronic Urticaria QoL questionnaire (CU-Q2oL) in urticaria. Among the many factors that variably contribute to QoL impairment, pruritus can represent the leading cause of patient discomfort. Biologic therapies significantly ameliorate QoL in atopic dermatitis, hereditary angioedema, mastocytosis and chronic urticaria. In general, adequate management strategies are essential for improving QoL in patients with allergic and immunologic skin diseases.
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Immunology,Immunology and Allergy