Issues of pathogenesis and treatment of contact dermatitis in children of the first year of life

Abstract

The article presents the pathogenetic features of dermatitis in children of the first year of life, features of the clinical picture and approaches to therapy. Contact dermatitis is a fairly common pathology in young children. Previously, it was believed that the clinical manifestations in this group of children were mainly associated with simple contact dermatitis (SCD), but in recent years, studies have shown that contact sensibilization is quite common, and currently the diagnosis of allergic contact dermatitis (ACD) is not uncommon, but timely anti-inflammatory therapy prevents the formation of a focus of chronic inflammation. The prevalence of SCD and ACD in children of the first year of life, as well as the severity of skin inflammation, is associated with the existing structural features of the skin. Changes in the structures of the epidermis and dermis, characteristic of this age period, lead to easier skin damage when exposed to various irritants, both mechanical and chemical in nature, and the penetration of allergens into the skin. The peculiarity of the structure of blood vessels and increased vascular permeability is an important factor in the development and longer existence of local inflammation. The main condition for the effectiveness of treatment of dermatitis is the cessation of exposure to the substances that caused their development, and the main means of treating these conditions are topical glucocorticosteroids (TGCS). The article discusses cases of SCD and ACD in children of the first year of life, in which methylprednisolone aceponate in the form of 0.1% cream was used for external therapy. The choice in favor of this TGCS was made due to the absence of halogens in the methylprednisolone aceponate formula, the possibility of use from 4 months of age and in sensitive areas. During treatment, all patients had a good clinical effect and no side effects. The use of methylprednisolone aceponate in the form of 0.1% cream for SCD and ACD in children of the first year of life is a highly effective and safe remedy.