Optogenetic investigation of neural circuits underlying brain disease in animal models
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn3171.pdf
Reference198 articles.
1. Deisseroth, K. Optogenetics. Nature Methods 8, 26–29 (2011).
2. Deisseroth, K. et al. Next-generation optical technologies for illuminating genetically targeted brain circuits. J. Neurosci. 26, 10380–10386 (2006).
3. Zhang, F. et al. The microbial opsin family of optogenetic tools. Cell 147, 1446–1457 (2011).
4. Airan, R. D., Thompson, K. R., Fenno, L. E., Bernstein, H. & Deisseroth, K. Temporally precise in vivo control of intracellular signalling. Nature 458, 1025–1029 (2009). This study developed the OptoXRs (photosensitive G protein-coupled receptors based on vertebrate opsin genes) for mammalian in vivo use and showed that light-activated intracellular signalling cascades could support conditioned place preference.
5. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neurosci. 8, 1263–1268 (2005). The initial demonstration of single-component optogenetics using a microbial opsin gene (in this case, a channelrhodopsin).
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