New potential binding determinant for hERG channel inhibitors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep24182.pdf
Reference56 articles.
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3. Curran, M. E. et al. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80, 795–803 (1995).
4. Brugada, R. et al. Sudden Death Associated with Short-QT Syndrome Linked to Mutations in HERG. Circulation 109, 30–35 (2004).
5. Fermini, B. & Fossa, A. A. The impact of drug-induced QT interval prolongation on drug discovery and development. Nat. Rev. Drug Discov. 2, 439–47 (2003).
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