HSCCC-based strategy for preparative separation of in vivo metabolites after administration of an herbal medicine: Saussurea laniceps, a case study

Author:

Yi Tao,Zhu Lin,Zhu Guo-Yuan,Tang Yi-Na,Xu Jun,Fan Jia-Yi,Zhao Zhong-Zhen,Chen Hu-Biao

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference40 articles.

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2. Kumar, G. N. & Surapaneni, S. Role of drug metabolism in drug discovery and development. Med Res Rev 21, 397–411 (2001).

3. He, S. M. et al. ADME properties of herbal medicines in humans: Evidence, challenges and strategies. Curr Pharm Design 17, 357–407 (2011).

4. Xiang, C. et al. From single compounds to herbal extract: A strategy to systematically characterize the metabolites of licorice in rats. Drug Metab Dispos 39, 1597–1608 (2011).

5. Huang, W. W. et al. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Arch Pharm Res 35, 1945–1952 (2012).

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