Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and31P and1H Nuclear Magnetic Resonance Spectroscopy. II. Changes during Ischaemia-Reference-Cited by-同舟云学术

Acute Cerebral Ischaemia: Concurrent Changes in Cerebral Blood Flow, Energy Metabolites, pH, and Lactate Measured with Hydrogen Clearance and31P and1H Nuclear Magnetic Resonance Spectroscopy. II. Changes during Ischaemia

Published:1987-08 Issue:4 Volume:7 Page:394-402
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Crockard H. Alan¹,Gadian David G.,Frackowiak Richard S. J.²¹,Proctor Edward,Allen Kathryn¹,Williams Stephen R.,Russell Ralph W. Ross¹

Affiliation:

1. Institute of Neurology, London, England

2. MRC Cyclotron Unit and Department of Medicine (Neurology), Hammersmith Hospital

Abstract

CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. This has been correlated with changes in local pH, tissue lactate, and phosphorus energy metabolites measured in the same animals with1H and31P nuclear magnetic resonance spectroscopy. We demonstrate a threshold flow value for the metabolic changes associated with energy failure at a level similar to the values previously reported for electrical failure and tissue water accumulation, but higher than that associated with breakdown of extracellular potassium homeostasis.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1987.82

Reference35 articles.

1. Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.

2. Evolution and resolution of oedema following severe temporary cerebral ischaemia in the gerbil.

3. Activity of phosphorylase in total global ischaemia in the rat heart A phosphorus-31 nuclear-magnetic-resonance study

4. Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon

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