Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis-Reference-Cited by-同舟云学术

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Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis

Published:2009-07-13 Issue:8 Volume:30 Page:1186-1194
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Chen Chien-yu,Chang Yea-huey,Bau Da-tian,Huang Hung-jin,Tsai Fuu-jen,Tsai Chang-hai,Chen Calvin Yu-chian

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://www.nature.com/articles/aps2009100.pdf

Reference40 articles.

1. Corbin JD, Francis SH . Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem 1999; 274: 13729–32.

2. Yoo HH, Kim NS, Im GJ, Kim DH . Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor, SK-3530, in rats. Acta Pharmacol Sin 2007; 28: 1247–53.

3. Whitehill D . Viagra, levitra, and cialis: What's the difference? S D J Med 2005; 58: 129–30.

4. Weeks JL, Zoraghi R, Beasley A, Sekhar KR, Francis SH, Corbin JD . High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5a1 (pde5) over pde11a4 suggests the absence of pde11a4 cross-reaction in patients. Int J Impot Res 2005; 17: 5–9.

5. Rao YJ, Xi L . Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts. Acta Pharmacol Sin 2009; 1: 1–24.

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