High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients

Author:

Weeks J L,Zoraghi R,Beasley A,Sekhar K R,Francis S H,Corbin J D

Publisher

Springer Science and Business Media LLC

Subject

Urology

Reference22 articles.

1. Weeks JL et al. Radioligand binding to the catalytic sites or allosteric sites of PDE5 and PDE11. In: Lugnier C (ed). Phosphodiesterase Methods and Protocols: Methods in Molecular Biology and Molecular Medicine. The Humana Press, Inc.: Towata, in press.

2. Charbonneau H . Structure–function relationships among cyclic nucleotide phosphodiesterases. In: Beavo JA, Houslay MD (eds). Cyclic Nucleotide Phosphodiesterases: Structure, Regulation, Drug Action. Wiley: New York, 1990 pp 267–296.

3. Burns F, Zhao AZ, Beavo JA . Cyclic nucleotide phosphodiesterases: gene complexity, regulation by phosphorylation, physiological implications [Review]. Adv Pharmacol (New York) 1996; 36: 29–48.

4. Francis SH, Corbin JD . Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit Rev Clin Lab Sci 1999; 36: 275–328.

5. Francis SH, Turko IV, Corbin JD . Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol 2001; 65: 1–52.

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