Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis-Reference-Cited by-同舟云学术

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Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis

Published:2009-03 Issue:3 Volume:30 Page:364-371
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Ma Ying,Lin Bi-rong,Lin Bei,Hou Sheng,Qian Wei-zhu,Li Jing,Tan Min,Ma Jian,Li Bo-hua,Wang Hao,Wen Ai-dong,Guo Ya-jun

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://www.nature.com/articles/aps200913.pdf

Reference15 articles.

1. Genovese MC, Becker JC, Schiff M, Luggen M, Sherrer Y, Kremer J, et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med 2005; 353: 1114–23.

2. Judith RA, Mark GL, Cynthia AG, Brian VJ, Michael TG, Bernard SG, et al. CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest 1999; 103: 1243–52.

3. Kremer JM, Westhovens R, Leon M, Eduardo DG, Rieke A, Serge S, et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 2003; 349: 1907–15.

4. Choy EH, Panayi GS . Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med 2001; 344: 907–16.

5. John JE, Timothy JS, James PA . CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. J Immunol 2006; 177: 1052–61.

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