PAR1 signaling: more good than harm?
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm0303-258.pdf
Reference15 articles.
1. Isermann, B. et al. The thrombomodulin–protein C system is essential for the maintenance of pregnancy. Nat. Med. 9 331–337 (2003).
2. Cheng, T. et al. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med. 338–342 (2003).
3. Bernard, G.R. et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344, 759–762 (2001).
4. Coughlin, S.R. & Camerer, E. PARticipation in inflammation. J. Clin. Invest. 111, 25–27 (2003).
5. Isermann, B. et al. Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. 108, 537–546 (2001).
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