Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide-Reference-Cited by-同舟云学术

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Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide

Published:2017-08-04 Issue:16 Volume:60 Page:7166-7185
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Jun¹,Sun Bin²,Zhao Xiaoyu¹,Xing Jie¹,Gao Yanhui¹,Chang Wenqiang¹,Ji Jianbo¹,Zheng Hongbo¹^ORCID,Cui Changyi¹,Ji Aiguo¹³,Lou Hongxiang¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China

2. National Glycoengineering Research Center, Shandong University, Jinan 250012, China

3. Weihai International Biotechnology Research and Development Centre, Shandong University, Weihai 264209, China

Funder

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00951

Reference47 articles.

1. PAR1 signaling: more good than harm?

2. Thrombin signalling and protease-activated receptors

3. Protease-activated receptor-1 antagonists in long-term antiplatelet therapy. Current state of evidence and future perspectives

4. Discovery of a vorapaxar analog with increased aqueous solubility

5. Thrombin-Receptor Antagonist Vorapaxar in Acute Coronary Syndromes

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