Crystal structure of the FTO protein reveals basis for its substrate specificity-Reference-Cited by-同舟云学术

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Crystal structure of the FTO protein reveals basis for its substrate specificity

Published:2010-04 Issue:7292 Volume:464 Page:1205-1209
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Han Zhifu,Niu Tianhui,Chang Junbiao,Lei Xiaoguang,Zhao Mingyan,Wang Qiang,Cheng Wei,Wang Jinjing,Feng Yi,Chai Jijie

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature08921.pdf

Reference30 articles.

1. Frayling, T. M. et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894 (2007)

2. Dina, C. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genet. 39, 724–726 (2007)

3. Fischer, J. et al. Inactivation of the Fto gene protects from obesity. Nature 458, 894–898 (2009)

4. Church, C. et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet. 5, e1000599 (2009)

5. Speakman, J. R., Rance, K. A. & Johnstone, A. M. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity 16, 1961–1965 (2008)

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