Atypical GATA transcription factor TRPS1 represses gene expression by recruiting CHD4/NuRD(MTA2) and suppresses cell migration and invasion by repressing TP63 expression

Author:

Wang Yuzhi,Lin Xue,Gong Xue,Wu Lele,Zhang Jun,Liu Weiguang,Li Jian,Chen Liming

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology

Reference40 articles.

1. Malik, T. H. et al. Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 20, 1715–1725 (2001).

2. Momeni, P. et al. Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Nat. Genet. 24, 71–74 (2000).

3. Li, Z. S. et al. Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma. Diagn. Pathol. 10, 167 (2015).

4. Hong, J., Sun, J. & Huang, T. Increased expression of TRPS1 affects tumor progression and correlates with patients’ prognosis of colon cancer. Biomed. Res. Int. 2013, 454085 (2013).

5. Radvanyi, L. et al. The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc. Natl. Acad. Sci. USA 102, 11005–11010 (2005).

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