Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt-Reference-Cited by-同舟云学术

Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt

Published:2018-01 Issue:1 Volume:7 Page:
ISSN:2157-9024
Container-title:Oncogenesis
language:en
Short-container-title:Oncogenesis

Author:

Katreddy Rajasekhara Reddy,Bollu Lakshmi Reddy,Su Fei,Xian Na,Srivastava Shivangi,Thomas Rintu,Dai Yubing,Wu Bing,Xu Yunlu,Rea Michael A.,Briggs James M.,Zhang Qingyuan,Lu Xiongbin,Huang Gangxiong,Weihua Zhang

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology

Link

http://www.nature.com/articles/s41389-017-0021-7.pdf

Reference39 articles.

1. Arteaga, C. L. & Engelman, J. A. ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell. 25, 282–303 (2014).

2. Mahipal, A., Kothari, N. & Gupta, S. Epidermal growth factor receptor inhibitors: coming of age. Cancer Control. 21, 74–79 (2014).

3. Melosky, B. Review of EGFR TKIs in metastatic NSCLC, including ongoing trials. Front. Oncol. 4, 244 (2014).

4. Tebbutt, N., Pedersen, M. W. & Johns, T. G. Targeting the ERBB family in cancer: couples therapy. Nat. Rev. Cancer 13, 663–673 (2013).

5. Ojemuyiwa, M. A., Madan, R. A. & Dahut, W. L. Tyrosine kinase inhibitors in the treatment of prostate cancer: taking the next step in clinical development. Expert. Opin. Emerg. Drugs 19, 459–470 (2014).

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