A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS

Author:

Iskandar Kartini1,Foo Jonathan12,Liew Angeline Qiu Xia12,Zhu Haiyuxin1,Raman Deepika1,Hirpara Jayshree L.3,Leong Yan Yi1,Babak Maria V.4,Kirsanova Anna A.4,Armand Anne-Sophie5,Oury Franck5,Bellot Gregory1,Pervaiz Shazib12678ORCID

Affiliation:

1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

2. Integrative Science and Engineering Programme (ISEP), NUS Graduate School (NUSGS), National University of Singapore, Singapore

3. Cancer Science Institute, National University of Singapore, Singapore

4. Drug Discovery Laboratory, Department of Chemistry, City University of Hong Kong, Hong Kong, SAR, China

5. Institut Necker Enfants Malades (INEM), INSERM U1151, Université Paris Cité, Paris, France

6. NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore

7. NUS Medicine Healthy Longevity Program, National University of Singapore, Singapore

8. National University Cancer Institute, National University Health System, Singapore

Funder

YLL School of Medicine, NUS

Publisher

Informa UK Limited

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