Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease-Reference-Cited by-同舟云学术

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease

Published:2022-10-13 Issue:4 Volume:44 Page:791-800
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Song Jia,Yang Rui-rui,Chang Jie,Liu Ya-dan,Lu Cheng-hao,Chen Li-fan,Guo Hao,Zhang Ying-hui,Fan Zi-sheng,Zhou Jing-yi,Zhou Gui-zhen,Zhang Ke-ke,Luo Xiao-min,Chen Kai-xian,Jiang Hua-liang,Zhang Su-lin,Zheng Ming-yue

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

https://www.nature.com/articles/s41401-022-01002-5.pdf

Reference32 articles.

1. Hu MM, Shu HB. Cytoplasmic mechanisms of recognition and defense of microbial nucleic acids. Annu Rev Cell Dev Biol. 2018;34:357–79.

2. Collins Angela C, Cai H, Li T, Franco Luis H, Li XD, Nair Vidhya R, et al. Cyclic GMP-AMP synthase is an innate immune DNA sensor for mycobacterium tuberculosis. Cell Host Microbe. 2015;17:820–8.

3. Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, et al. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014;6:421–30.

4. Wu J, Sun L, Chen X, Du F, Shi H, Chen C, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013;339:826–30.

5. Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013;339:786–91.

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