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Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy

Published:2012-12-16 Issue:1 Volume:15 Page:103-112
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Fievet Bruno Thomas,Rodriguez Josana,Naganathan Sundar,Lee Christine,Zeiser Eva,Ishidate Takao,Shirayama Masaki,Grill Stephan,Ahringer Julie

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/ncb2639.pdf

Reference49 articles.

1. Lehner, B., Crombie, C., Tischler, J., Fortunato, A. & Fraser, A. G. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signalling pathways. Nat. Gen. 38, 896–903 (2006).

2. Byrne, A. B. et al. A global analysis of genetic interactions in Caenorhabditis elegans. J. Biol. 6, 8 (2007).

3. Sandmann, T. & Boutros, M. Screens, maps networks: from genome sequences to personalized medicine. Curr. Opin. Genet. Dev. 22, 36–44 (2012).

4. Costanzo, M. et al. The genetic landscape of a cell. Science 327, 425–431 (2010).

5. Labbe, J. C., Pacquelet, A., Marty, T. & Gotta, M. A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans. Genetics 174, 285–295 (2006).

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