Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2336.pdf
Reference140 articles.
1. Gosling, K. M. et al. A mutation in a chromosome condensin II subunit, kleisinβ, specifically disrupts T cell development. Proc. Natl Acad. Sci. USA 104, 12445–12450 (2007). This study describes the sensitivity of thymocytes to global impairments in basic cellular processes, with a partial block at the double-negative stage of thymocyte development in mice with a point mutation in the ubiquitious chromosome component kleisin-β.
2. Anderson, S. J. et al. Ablation of ribosomal protein L22 selectively impairs αβT cell development by activation of a p53-dependent checkpoint. Immunity 26, 759–772 (2007).
3. Deutschbauer, A. M. et al. Mechanisms of haploinsufficiency revealed by genome-wide profiling in yeast. Genetics 169, 1915–1925 (2005).
4. Giaever, G. et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature 418, 387–391 (2002).
5. Fischer, A. et al. Naturally occurring primary deficiencies of the immune system. Annu. Rev. Immunol. 15, 93–124 (1997).
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