Affiliation:
1. Unité INSERM U 429, Hôpital Necker-Enfants Malades—149, Rue de Sèvres, Paris cedex 15, 75 743 France
Abstract
▪ Abstract Naturally occurring genetic disorders of the immune system provide many models for the study of its development and function. In a way, their analysis complements the information provided by the generation of genetic defects in mice created using homologous recombination techniques. In this review, the recent findings made in three areas are focused upon deficiencies in T cell differentiation and in T lymphocyte activation, and on the control process of peripheral immune response.
Subject
Immunology,Immunology and Allergy
Cited by
143 articles.
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