Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology,Biochemistry,Biotechnology
Link
http://www.nature.com/articles/nmeth.3684.pdf
Reference140 articles.
1. Chylinski, K., Makarova, K.S., Charpentier, E. & Koonin, E.V. Classification and evolution of type II CRISPR-Cas systems. Nucleic Acids Res. 42, 6091–6105 (2014).
2. Makarova, K.S. et al. An updated evolutionary classification of CRISPR-Cas systems. Nat. Rev. Microbiol. 13, 722–736 (2015).
3. Sontheimer, E.J. & Barrangou, R. The bacterial origins of the CRISPR genome-editing revolution. Hum. Gene Ther. 26, 413–424 (2015).
4. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).This study describes the minimal components required to program a type II CRISPR-Cas9 system for targeted DNA cleavage in vitro and demonstrates that crRNA and tracrRNA can be joined into an sgRNA to generate a two-component system for site-specific editing.
5. Urnov, F.D., Rebar, E.J., Holmes, M.C., Zhang, H.S. & Gregory, P.D. Genome editing with engineered zinc finger nucleases. Nat. Rev. Genet. 11, 636–646 (2010).
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