CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy

Author:

Kong Huimin1,Yi Ke1,Mintz Rachel L.2,Wang Bin3,Xu Yanteng1,Lao Yeh-Hsing4,Tao Yu1ORCID,Li Mingqiang1ORCID

Affiliation:

1. Laboratory of Biomaterials and Translational Medicine, Center for Nanomedicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China

2. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA

3. Department of Infectious Diseases, Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun 130061, China

4. Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA

Abstract

This feature article summarises the latest advances, potential challenges, and future prospects of CRISPR/Cas gene-editing technologies in conjunction with emerging nanodevices for the refinement of precision liquid biopsy techniques.

Funder

Guangdong Provincial Pearl River Talents Program

National Natural Science Foundation of China

China Primary Health Care Foundation

National Key Research and Development Program of China

Guangzhou Municipal Science and Technology Project

Publisher

Royal Society of Chemistry (RSC)

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