Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides-Reference-Cited by-同舟云学术

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Published:2017-08-21 Issue:9 Volume:35 Page:845-851
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Iwamoto Naoki,Butler David C D,Svrzikapa Nenad,Mohapatra Susovan,Zlatev Ivan,Sah Dinah W Y,Meena ,Standley Stephany M,Lu Genliang,Apponi Luciano H,Frank-Kamenetsky Maria,Zhang Jason Jingxin,Vargeese Chandra,Verdine Gregory L

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.3948.pdf

Reference38 articles.

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2. Deleavey, G.F. & Damha, M.J. Designing chemically modified oligonucleotides for targeted gene silencing. Chem. Biol. 19, 937–954 (2012).

3. Swayze, E.E. et al. Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals. Nucleic Acids Res. 35, 687–700 (2007).

4. Sharma, V.K., Sharma, R.K. & Singh, S.K. Antisense oligonucleotides: modifications and clinical trials. MedChemComm. 5, 1454–1471 (2014).

5. Eckstein, F. Phosphorothioates, essential components of therapeutic oligonucleotides. Nucleic Acid Ther. 24, 374–387 (2014).

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