Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
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Published:2023-03-02
Issue:5
Volume:7
Page:790-801
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ISSN:2397-3374
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Container-title:Nature Human Behaviour
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language:en
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Short-container-title:Nat Hum Behav
Author:
Mathieson IainORCID, Day Felix R.ORCID, Barban Nicola, Tropf Felix C., Brazel David M., van Heemst Diana, Vaez AhmadORCID, van Zuydam Natalie, Bitarello Bárbara D.ORCID, Gardner Eugene J.ORCID, Akimova Evelina T.ORCID, Azad Ajuna, Bergmann SvenORCID, Bielak Lawrence F.ORCID, Boomsma Dorret I.ORCID, Bosak Kristina, Brumat Marco, Buring Julie E., Cesarini David, Chasman Daniel I.ORCID, Chavarro Jorge E.ORCID, Cocca MassimilianoORCID, Concas Maria PinaORCID, Davey Smith GeorgeORCID, Davies GailORCID, Deary Ian J., Esko Tõnu, Faul Jessica D., Franco OscarORCID, Ganna AndreaORCID, Gaskins Audrey J.ORCID, Gelemanovic Andrea, de Geus Eco J. C., Gieger ChristianORCID, Girotto GiorgiaORCID, Gopinath Bamini, Grabe Hans JörgenORCID, Gunderson Erica P.ORCID, Hayward Caroline, He ChunyanORCID, van Heemst Diana, Hill W. David, Hoffmann Eva R.ORCID, Homuth GeorgORCID, Hottenga Jouke JanORCID, Huang Hongyang, Hyppӧnen ElinaORCID, Ikram M. ArfanORCID, Jansen RickORCID, Johannesson MagnusORCID, Kamali ZohaORCID, Kardia Sharon L. R., Kavousi MaryamORCID, Kifley AnnetteORCID, Kiiskinen TuomoORCID, Kraft PeterORCID, Kühnel Brigitte, Langenberg ClaudiaORCID, Liew Gerald, van der Most Peter J., Lind Penelope A.ORCID, Luan Jian’anORCID, Mägi Reedik, Magnusson Patrik K. E.ORCID, Mahajan AnubhaORCID, Martin Nicholas G., Mbarek HamdiORCID, McCarthy Mark I., McMahon George, Medland Sarah E., Meitinger Thomas, Metspalu AndresORCID, Mihailov Evelin, Milani LiliORCID, Missmer Stacey A., Mitchell Paul, Møllegaard StineORCID, Mook-Kanamori Dennis O., Morgan AnnaORCID, van der Most Peter J.ORCID, de Mutsert Renée, Nauck MatthiasORCID, Nolte Ilja M.ORCID, Noordam RaymondORCID, Penninx Brenda W. J. H., Peters AnnetteORCID, Peyser Patricia A.ORCID, Polašek Ozren, Power Chris, Pribisalic AjkaORCID, Redmond Paul, Rich-Edwards Janet W., Ridker Paul M., Rietveld Cornelius A.ORCID, Ring Susan M.ORCID, Rose Lynda M., Rueedi Rico, Shukla Vallari, Smith Jennifer A.ORCID, Stankovic StasaORCID, Stefánsson Kári, Stöckl Doris, Strauch Konstantin, Swertz Morris A., Teumer AlexanderORCID, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Thurik A. RoyORCID, Timpson Nicholas J.ORCID, Turman Constance, Uitterlinden André G.ORCID, Waldenberger MelanieORCID, Wareham Nicholas J.ORCID, Weir David R.ORCID, Willemsen Gonneke, Zhao Jing Hau, Zhao WeiORCID, Zhao YajieORCID, Snieder HaroldORCID, den Hoed MarcelORCID, Ong Ken K.ORCID, Mills Melinda C.ORCID, Perry John R. B.ORCID, , , ,
Funder
RCUK | Medical Research Council
Publisher
Springer Science and Business Media LLC
Subject
Behavioral Neuroscience,Experimental and Cognitive Psychology,Social Psychology
Reference71 articles.
1. Day, F. R. et al. Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome. Nat. Commun. 6, 8464 (2015). 2. Day, F. et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 14, e1007813 (2018). 3. Censin, J. C., Bovijn, J., Holmes, M. V. & Lindgren, C. M. Commentary: Mendelian randomization and women’s health. Int. J. Epidemiol. 48, 830–833 (2019). 4. O’Connor, L. J. et al. Extreme polygenicity of complex traits is explained by negative selection. Am. J. Hum. Genet. 105, 456–476 (2019). 5. Weissbrod, O. et al. Functionally informed fine-mapping and polygenic localization of complex trait heritability. Nat. Genet. 52, 1355–1363 (2020).
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