An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron-Reference-Cited by-同舟云学术

An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Published:2022-04-27 Issue:5 Volume:7 Page:716-725
ISSN:2058-5276
Container-title:Nature Microbiology
language:en
Short-container-title:Nat Microbiol

Author:

Quan Bao-Xue,Shuai Huiping^ORCID,Xia An-Jie^ORCID,Hou Yuxin,Zeng Rui,Liu Xin-Lei,Lin Gui-Feng,Qiao Jing-Xin,Li Wen-Pei,Wang Fa-Lu,Wang Kai,Zhou Ren-Jie,Yuen Terrence Tsz-Tai,Chen Ming-Xin,Yoon Chaemin,Wu Ming,Zhang Shi-Yu,Huang Chong,Wang Yi-Fei,Yang Wei,Tian Chenyu,Li Wei-Min^ORCID,Wei Yu-Quan,Yuen Kwok-Yung^ORCID,Chan Jasper Fuk-Woo^ORCID,Lei Jian^ORCID,Chu Hin^ORCID,Yang Shengyong^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology

Link

https://www.nature.com/articles/s41564-022-01119-7.pdf

Reference44 articles.

1. Harvey, W. T. et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat. Rev. Microbiol. 19, 409–424 (2021).

2. Shuai, H. et al. Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron. Nature 603, 693–699 (2022).

3. Liu, L. et al. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature 602, 676–681 (2021).

4. Kissler, S. M., Tedijanto, C., Goldstein, E., Grad, Y. H. & Lipsitch, M. Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science 368, 860–868 (2020).

5. Telenti, A. et al. After the pandemic: perspectives on the future trajectory of COVID-19. Nature 596, 495–504 (2021).

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