Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies

Author:

Dampalla Chamandi S.1ORCID,Kim Yunjeong2,Zabiegala Alexandria2,Howard Dennis J.1,Nguyen Harry Nhat1,Madden Trent K.1,Thurman Hayden A.1,Cooper Anne3ORCID,Liu Lijun3,Battaile Kevin P.4ORCID,Lovell Scott3,Chang Kyeong-Ok2,Groutas William C.1ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States

2. Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, United States

3. Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States

4. NYX, New York Structural Biology Center, Upton, New York 11973, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Reference79 articles.

1. A new coronavirus associated with human respiratory disease in China

2. Middle East respiratory syndrome

3. COVID-19 Map; Johns Hopkins Coronavirus Resource Center. https://coronavirus.jhu.edu/map.html (accessed Feb 25, 2023).

4. COVID-19 Crisis Response Approach-June; World Bank Group. 2020. https://documents1.worldbank.org/curated/en/136631594937150795/pdf/World-Bank-Group-COVID-19-Crisis-Response-Approach-Paper-Saving-Lives-Scaling-up-Impact-and-Getting-Back-on-Track.pdf (accessed Feb 25, 2023).

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