DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms
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Published:2023-11-29
Issue:12
Volume:8
Page:2326-2337
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ISSN:2058-5276
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Container-title:Nature Microbiology
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language:en
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Short-container-title:Nat Microbiol
Author:
Carrión OrnellaORCID, Li Chun-YangORCID, Peng MingORCID, Wang JinyanORCID, Pohnert GeorgORCID, Azizah MuhaiminatulORCID, Zhu Xiao-Yu, Curson Andrew R. J., Wang Qing, Walsham Keanu S., Zhang Xiao-HuaORCID, Monaco Serena, Harvey James M.ORCID, Chen Xiu-LanORCID, Gao Chao, Wang Ning, Wang Xiu-Juan, Wang Peng, Giovanonni Stephen J.ORCID, Lee Chih-Ping, Suffridge Christopher P., Zhang Yu, Luo Ziqi, Wang Dazhi, Todd Jonathan D.ORCID, Zhang Yu-ZhongORCID
Abstract
AbstractDimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase ‘Ddd’ or ‘Alma’ enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.
Funder
Leverhulme Trust National Science Foundation of China | International Cooperation and Exchange Programme
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology
Reference67 articles.
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