Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema-Reference-Cited by-同舟云学术

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Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

Published:2003-03 Issue:6928 Volume:422 Page:169-173
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Morris David G.,Huang Xiaozhu,Kaminski Naftali,Wang Yanli,Shapiro Steven D.,Dolganov Gregory,Glick Adam,Sheppard Dean

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature01413.pdf

Reference27 articles.

1. Munger, J. S. et al. The integrin αvβ6 binds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319–328 (1999)

2. Pittet, J. F. et al. TGF-β is a critical mediator of acute lung injury. J. Clin. Invest. 107, 1537–1544 (2001)

3. Kaminski, N. et al. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Natl Acad. Sci. USA 97, 1778–1783 (2000)

4. Werb, Z. & Gordon, S. Elastase secretion by stimulated macrophages. Characterization and regulation. J. Exp. Med. 142, 361–377 (1975)

5. Shapiro, S. D. et al. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J. Biol. Chem. 267, 4664–4671 (1992)

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