Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease-Reference-Cited by-同舟云学术

Identification of Siglec-1-negative alveolar macrophages with proinflammatory phenotypes in chronic obstructive pulmonary disease

Published:2024-06-01 Issue:6 Volume:326 Page:L672-L686
ISSN:1040-0605
Container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology
language:en
Short-container-title:American Journal of Physiology-Lung Cellular and Molecular Physiology

Author:

Saito Takuya¹^ORCID,Fujino Naoya¹^ORCID,Kyogoku Yorihiko¹,Yamada Mitsuhiro¹^ORCID,Okutomo Koji¹,Ono Yoshinao¹,Konno Shuichi¹,Endo Takuto¹,Itakura Koji¹,Matsumoto Shuichiro¹,Sano Hirohito¹,Aizawa Hiroyuki¹,Numakura Tadahisa¹,Onodera Katsuhiro¹,Okada Yoshinori²,Hussell Tracy³,Ichinose Masakazu⁴,Sugiura Hisatoshi¹

Affiliation:

1. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

2. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

3. Lydia Becker Institute of Immunology and Inflammation, The University of Manchester, Manchester, United Kingdom

4. Academic Center, Osaki Citizen Hospital, Miyagi, Japan

Abstract

Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation in the airway. We find that Siglec-1-negative alveolar macrophages have a wide range of proinflammatory landscapes and a protease-expressing phenotype. Moreover, this subset is associated with the pathogenesis of COPD and responds to viral stimuli.

Funder

Japanese Respiratory Foundation

MEXT | Japan Society for the Promotion of Science

Tohoku University

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajplung.00303.2023

Reference34 articles.

1. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis

2. New anti-inflammatory targets for chronic obstructive pulmonary disease

3. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

4. Alveolar macrophages: plasticity in a tissue-specific context

5. Impaired Phagocytosis of NontypeableHaemophilus influenzaeby Human Alveolar Macrophages in Chronic Obstructive Pulmonary Disease

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