Resistance to therapy caused by intragenic deletion in BRCA2-Reference-Cited by-同舟云学术

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Resistance to therapy caused by intragenic deletion in BRCA2

Published:2008-02 Issue:7182 Volume:451 Page:1111-1115
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Edwards Stacey L.,Brough Rachel,Lord Christopher J.,Natrajan Rachael,Vatcheva Radost,Levine Douglas A.,Boyd Jeff,Reis-Filho Jorge S.,Ashworth Alan

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature06548.pdf

Reference30 articles.

1. Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434, 917–921 (2005)

2. Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913–917 (2005)

3. Tutt, A. et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J. 20, 4704–4716 (2001)

4. Moynahan, M. E., Pierce, A. J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell 7, 263–272 (2001)

5. Domchek, S. M. & Weber, B. L. Clinical management of BRCA1 and BRCA2 mutation carriers. Oncogene 25, 5825–5831 (2006)

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