DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis-Reference-Cited by-同舟云学术

DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis

Published:2024-08-17 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Huang Yuxin,Li Wenjing^ORCID,Foo Tzeh^ORCID,Ji Jae-Hoon,Wu Bo,Tomimatsu Nozomi,Fang Qingming^ORCID,Gao Boya,Long Melissa,Xu Jingfei,Maqbool Rouf,Mukherjee Bipasha,Ni Tengyang,Alejo Salvador^ORCID,He Yuan^ORCID,Burma Sandeep^ORCID,Lan Li,Xia Bing^ORCID,Zhao Weixing^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Cancer Prevention and Research Institute of Texas

U.S. Department of Health & Human Services | NIH | National Cancer Institute

American Cancer Society

V Foundation for Cancer Research

Max and Minnie Tomerlin Voelcker Fund

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-51557-6.pdf

Reference61 articles.

1. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789–792 (1995).

2. Gayther, S. A. et al. Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene. Nat. Genet. 15, 103–105 (1997).

3. Wong, A. K., Pero, R., Ormonde, P. A., Tavtigian, S. V. & Bartel, P. L. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J. Biol. Chem. 272, 31941–31944 (1997).

4. Esashi, F. et al. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434, 598–604 (2005).

5. San Filippo, J., Sung, P. & Klein, H. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77, 229–257 (2008).