Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

Author:

Wang I‐Ming1,Zhang Bin2345,Yang Xia56,Zhu Jun2345,Stepaniants Serguei7,Zhang Chunsheng1,Meng Qingying6,Peters Mette5,He Yudong8,Ni Chester9,Slipetz Deborah10,Crackower Michael A10,Houshyar Hani11,Tan Christopher M12,Asante‐Appiah Ernest10,O'Neill Gary10,Jane Luo Mingjuan13,Thieringer Rolf14,Yuan Jeffrey15,Chiu Chi‐Sung11,Yee Lum Pek16,Lamb John17,Boie Yves18,Wilkinson Hilary A19,Schadt Eric E2345,Dai Hongyue20,Roberts Christopher20

Affiliation:

1. Informatics and Analysis, Merck Research Laboratories, Merck & Co., Inc. West Point PA USA

2. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine New York NY USA

3. Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine New York NY USA

4. Graduate School of Biological Sciences, Mount Sinai School of Medicine New York NY USA

5. Sage Bionetworks Seattle WA USA

6. Department of Integrative Biology and Physiology, University of California Los Angeles CA USA

7. Covance Genomics Laboratory Seattle WA USA

8. Investigative Toxicology Department, Amgen Seattle WA USA

9. Systems Immunology, Benaroya Research Institute Seattle WA USA

10. Department of Respiratory and Inflammation, Merck Research Laboratories, Merck & Co., Inc. Boston MA USA

11. In Vivo Pharmacology, Merck Research Laboratories, Merck & Co., Inc. Boston MA USA

12. In Vivo Pharmacology, Merck Research Laboratories, Merck & Co., Inc. Kenilworth NJ USA

13. Lilly Research Laboratories, Lilly Corporate Center Indianapolis IN USA

14. External Scientific Affairs, Merck Research Laboratories, Merck & Co., Inc. Rahway NJ USA

15. World Wide Regulatory Affairs, Merck Research Laboratories, Merck & Co., Inc. Rahway NJ USA

16. Product, Ayasdi Inc. Palo Alto CA USA

17. Oncology Research Unit, Pfizer San Diego CA USA

18. Genomics Platform, Broad Institute Cambridge MA USA

19. Department of Respiratory and Inflammation, Merck Research Laboratories, Merck & Co., Inc. Rahway NJ USA

20. Informatics and Analysis, Merck Research Laboratories, Merck & Co., Inc. Boston MA USA

Publisher

EMBO

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

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