Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage-Reference-Cited by-同舟云学术

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Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage

Published:2024-08-10 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Gong Ke,Xue Chao,Feng Zian,Pan Ruru,Wang Mengyao,Chen Shasha,Chen Yuanli^ORCID,Guan Yudong,Dai Lingyun^ORCID,Zhang Shuang,Jiang Liwei,Li Ling,Wang Bei,Yin Zequn,Ma Likun^ORCID,Iwakiri Yasuko^ORCID,Tang Junming^ORCID,Liao Chenzhong,Chen Houzao^ORCID,Duan Yajun^ORCID

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-51352-3.pdf

Reference61 articles.

1. Cantley, J. & Ashcroft, F. M. Q&A: insulin secretion and type 2 diabetes: why do beta-cells fail? BMC Biol. 13, 33 (2015).

2. Demir, S., Nawroth, P. P., Herzig, S. & Ekim Ustunel, B. Emerging targets in type 2 diabetes and diabetic complications. Adv. Sci. 8, e2100275 (2021).

3. Weir, G. C., Gaglia, J. & Bonner-Weir, S. Inadequate beta-cell mass is essential for the pathogenesis of type 2 diabetes. Lancet Diabetes Endocrinol. 8, 249–256 (2020).

4. Haedersdal, S., Andersen, A., Knop, F. K. & Vilsboll, T. Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases. Nat. Rev. Endocrinol. 19, 321–335 (2023).

5. Holst, J. J. Glucagon-like peptide-1: are its roles as endogenous hormone and therapeutic wizard congruent? J. Intern. Med. 291, 557–573 (2022).

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