Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

Published:2008-03-13 Issue:9 Volume:22 Page:1807-1811
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Metzler M,Staege M S,Harder L,Mendelova D,Zuna J,Fronkova E,Meyer C,Flohr T,Bednarova D,Harbott J,Langer T,Gesk S,Trka J,Siebert R,Dingermann T,Marschalek R,Niemeyer C,Rascher W

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu200850.pdf

Reference8 articles.

1. Aplan PD, Chervinsky DS, Stanulla M, Burhans WC . Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 1996; 87: 2649–2658.

2. Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat Genet 2003; 33: 208–213.

3. Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T et al. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). Genes Chromosomes Cancer 2007; 46: 813.

4. Meyer C, Schneider B, Reichel M, Angermueller S, Strehl S, Schnittger S et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005; 102: 449–454.

5. Whitmarsh RJ, Saginario C, Zhuo Y, Hilgenfeld E, Rappaport EF, Megonigal MD et al. Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing. Oncogene 2003; 22: 8448–8459.

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