Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR-Reference-Cited by-同舟云学术

Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR

Published:2008-07-10 Issue:2 Volume:23 Page:396-399
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Oehler V G,Qin J,Ramakrishnan R,Facer G,Ananthnarayan S,Cummings C,Deininger M,Shah N,McCormick F,Willis S,Daridon A,Unger M,Radich J P

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2008183.pdf

Reference8 articles.

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2. Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102: 276–283.

3. Soverini S, Martinelli G, Rosti G, Bassi S, Amabile M, Poerio A et al. ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party on Chronic Myeloid Leukemia. J Clin Oncol 2005; 23: 4100–4109.

4. Ottesen EA, Hong JW, Quake SR, Leadbetter JR . Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science 2006; 314: 1464–1467.

5. Baker SG, Kramer BS, McIntosh M, Patterson BH, Shyr Y, Skates S . Evaluating markers for the early detection of cancer: overview of study designs and methods. Clin Trials 2006; 3: 43–56.

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